Flumazenil (Flumazenil)
Overview of Flumazenil
Flumazenil is a 1,4- benzodiazepine derivative. Flumazenil is the only benzodiazepine receptor antagonist available for clinical use at present. Flumazenil is approved for use in reversing the sedative effects of certain drugs (benzodiazipines). Flumazenil is used to counteract effects of benzodiazipines overdose. Flumazenil is administered intravenously.
Indication of Flumazenil
Flumazenil is primarily indicated in conditions like Poisoning of benzodiazepine, Reversal of sedative effects of benzodiazepines in anaesthetic, Unconciousness.
Contraindication of Flumazenil
Flumazenil is contraindicated in conditions like Epilepsy,Neuromuscular blockade.
Side Effects of Flumazenil
The severe or irreversible adverse effects of Flumazenil, which give rise to further complications include Cardiac arrhythmias, Cardiac arrhythmias.,Flumazenil produces potentially life-threatening effects which include Raised intracranial pressure. which are responsible for the discontinuation of Flumazenil therapy.,The signs and symptoms that are produced after the acute overdosage of Flumazenil include Headache, Anxiety, Facial flushing.,The symptomatic adverse reactions produced by Flumazenil are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Anxiety, Confusion, Flushing, Agitation, Facial erythema, Resedation, Confusion, dizziness.
Precautions of Flumazenil
Flumazenil should be used with caution in patients with history of seizures, panic attacks, alcohol or drug dependency, breathing disorders, heart disease, liver disease, head injury or if have any allergy. This drug should be used only if clearly needed during pregnancy or lactation. This drug is not recommended for use in children.