Flucytosine (Flucytosine)
Overview of Flucytosine
Flucytosine is antifungal agent. Flucytosine is fluorinated pyrimidine. its spectrum of activity is restricted to some Candida species and the dematiaceous mold. It was discovered in 1957 during a search for novel anticancerous agents. While devoid of anticancer properties, it became apparent that it was a potent antifungal agent. Flucytosine is a water soluble pyrimidine analog that is related to the chemotherapeutic agent fluorouracil. Flucytosine is administered orally.
Indication of Flucytosine
Flucytosine is primarily indicated in conditions like Candidosis, Cryptococcosis, Meningitis, Obsessive-compulsive disorders, Torulopsosis, and can also be given in adjunctive therapy as an alternative drug of choice in Osteoporosis in men, Suppression of supraventricular tachycardias and ventricular arrhythmias.
Contraindication of Flucytosine
No data regarding the contra indications of Flucytosine is available.
Side Effects of Flucytosine
The severe or irreversible adverse effects of Flucytosine, which give rise to further complications include Hypokalemia, Hepatic necrosis, Elevated alkaline phosphatase concentration, Deaths, Elevated transaminases, Disturbed liver function, Elevated alkaline phosphatase concentration.,Flucytosine produces potentially life-threatening effects which include Thrombocytopenia, Leucopenia, Bone marrow toxicity, Death. which are responsible for the discontinuation of Flucytosine therapy.,The symptomatic adverse reactions produced by Flucytosine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Diarrhea, Skin rashes, Sedation, Nausea and vomiting, Convulsions, Skin rashes.
Precautions of Flucytosine
Flucytosine should be used only if clearly needed during pregnancy. It should be used with caution in patients with any pre-existing liver disease, kidney disease, bone marrow disorders or any allergy. Blood count should be mointered during therapy.