Amphotericin B (Amphotericin B)
Overview of Amphotericin B
Amphotericin B is antifungal antibiotic produced by Streptomyces nodosus. Amphotericin B is amphoteric polyene macrolide (containing many double bonds and a large lactone ring of 12 or more atoms). It has a broad spectrum of action and active against yeasts, organisms causing endemic mycoses and pathogenic molds.Amphotericin B is used topically for skin infections and intravenously for severe generalized fungal infections.
Indication of Amphotericin B
Amphotericin B is primarily indicated in conditions like Candidiasis of mouth, Cutaneouus and mucocutaneous candidiasis, Denture stomatitis, Intestinal candidiasis, Severe shock due for example to cardiac arrest, Systemic mycoses, Vaginal candidiasis, Visceral leishmaniasis.
Contraindication of Amphotericin B
Amphotericin B is contraindicated in conditions like Hypersensitivity.
Side Effects of Amphotericin B
The severe or irreversible adverse effects of Amphotericin B, which give rise to further complications include Renal damage, Anaemia.,Amphotericin B produces potentially life-threatening effects which include Anaphylactic reactions. which are responsible for the discontinuation of Amphotericin B therapy.,The symptomatic adverse reactions produced by Amphotericin B are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Anorexia, Fever, Abdominal pain, Chills, Azotemia.
Precautions of Amphotericin B
Amphotericin B should be used with caution in patients with heart disease, liver disease, kidney disease or any allergies. This medication should be used only if clearly needed during pregnancy. Use of this medication is not recommended during lactation.