Fenfluramine Hcl (Fenfluramine Hcl)
Overview of Fenfluramine Hcl
Fenfluramine Hcl is antiobesity drug and has anorectic effects. Fenfluramine Hcl is a racemic chemical, closely related to amphetamine. It was introduced as an anorexigenic drug more than a decade ago in Europe. its d-isomer, d-fenfluramine is about twice as potent an anorexigenic drug as fenfluramine, suggesting that all of the fenfluramine activity reside in the d-form.
Indication of Fenfluramine Hcl
Fenfluramine Hcl is primarily indicated in conditions like Obesity, and can also be given in adjunctive therapy as an alternative drug of choice in Hypertension, Maturity onset diabetes.
Contraindication of Fenfluramine Hcl
Fenfluramine (HCl) is contraindicated in conditions like Depression,Mania,Cardiovascular disease.
Side Effects of Fenfluramine Hcl
The severe or irreversible adverse effects of Fenfluramine (HCl), which give rise to further complications include Tachycardia, Impotence, Anorexia, Coma, Depression, Dizziness, Respiratory depression, Abdominal cramps.,Fenfluramine (HCl) produces potentially life-threatening effects which include Blood dyscrasias, Pulmonary hypertension. which are responsible for the discontinuation of Fenfluramine (HCl) therapy.,The signs and symptoms that are produced after the acute overdosage of Fenfluramine (HCl) include Flushing, Tachycardia, Cardiac arrhythmias, Convulsions, Coma, Hyperthermia, Hallucinations, Sweating, Tachypnea, Hyperpyrexia, Tremor, Mydriasis, Nystagmus, Excitation, Sweating, Increased tendon reflexes, Chest pain.,The symptomatic adverse reactions produced by Fenfluramine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Drowsiness, Irritability, Nausea, Vomiting, Diarrhea, Restlessness, Insomnia, Dry mouth, Rashes, Lethargy, Impotence, Loss of libido, Urinary frequency, Dry mouth, dizziness.
Precautions of Fenfluramine Hcl
Avoid Fenfluramine in patients with pulmonary hypertension, past or current history of cardiovascular or cerebrovascular disease, psychiatric disease, glaucoma, epilepsy, history of drug abuse. It should be used with extreme caution in elderly or during pregnancy or lactation. Avoid abrupt withdrawal. Patient should observe caution while driving or performing other task requiring alertness because it may produce dizziness, extreme fatigue and depression. It should be usedwith caution and monitor blood pressure (B.P) in patients with mild hypertension. Dose titration and dose discontinuance may be necessary in epileptic patients. Height and weight should be monitored as fenfluramine may cause growth retardation.