Ethacrynic Acid (Ethacrynic Acid)
Overview of Ethacrynic Acid
Ethacrynic Acid is an antihypertensive agent. Ethacrynic Acid is a prototype drug of Loop Diuretics. Loop diuretics have a much greater diuretic effects than the thiazides. Ethacrynic Acid is a phenoxyacetic acid derivative containing an adjacent ketone and methylene group. The methylene group forms an adduct with the free sulfhydryl group of cysteine. The cysteine adduct appears to be the active form of the drug. It increases the urination and decreases the amount of water retained in the body. Ethacynic acid is especially useful in patients who require an agent with greater diuretic potential than those commonly employed.
Indication of Ethacrynic Acid
Ethacrynic Acid is primarily indicated in conditions like Ascites in malignancy, Edema caused by nephrotic syndrome, Idiopathic edema, Liver disease associated with ascites, Lymphoedema, Pulmonary edema, Refractory edema in congestive heart failure.
Contraindication of Ethacrynic Acid
Ethacrynic Acid is contraindicated in conditions like Gout,Anuria,Oliguria,Fluid depletion,Renal failure associated with hepatic coma.
Side Effects of Ethacrynic Acid
The severe or irreversible adverse effects of Ethacrynic Acid, which give rise to further complications include Hallucinations, Thrombocytopenia, Hallucinations, Jaundice, Jaundice, Acute pancreatitis, Acute pancreatitis, Hyperglycemia, Mania, Hypoglycemia, Hyperglycemia.,Ethacrynic Acid produces potentially life-threatening effects which include Electrolyte disturbances, Ototoxicity, Gastrointestinal hemorrhage. which are responsible for the discontinuation of Ethacrynic Acid therapy.,The signs and symptoms that are produced after the acute overdosage of Ethacrynic Acid include Postural hypotension, Sodium and fluid depletion.,The symptomatic adverse reactions produced by Ethacrynic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Anorexia, Diarrhea, Urinary retensionX, GI hemorrhage, Abdominal discomfort.
Precautions of Ethacrynic Acid
Ethacrynic acid should be used with caution in patients with history especially of kidney problems, unusual decrease in urine output, liver disease and of any drug allergy. This drug can reduce the potassium levels in blood, so take potassium supplements. It should be used with caution during pregnancy or lactation.