Droperidol (Droperidol)
Overview of Droperidol
Droperidol is a drug of the butyrophenone series. Droperidol is used for its antianxiety, sedative, tranquilizer and antiemetic effects. Droperidol is a component of neuroleptic anesthesia. Droperidol is used in surgical and diagnostic procedures for its calming effect. It decreases anxiety and pain, reduces nausea and vomiting induced by cancer chemotherapy and may be effective during labor and delivery. Droperidol is administered intramuscularly or intravenously.
Indication of Droperidol
Droperidol is primarily indicated in conditions like Aggression, Anxiety, General anaesthesia, Hyperactivity, Hyperemesis gravidarum, Nausea and vomiting, Regional anaesthesia, Schizophrenia, and can also be given in adjunctive therapy as an alternative drug of choice in Induction, Induction and maintenance of anaesthesia, Sedation, Surgical anaesthesia.
Contraindication of Droperidol
Droperidol is contraindicated in conditions like Parkinson's disease,Comatose states.
Side Effects of Droperidol
The severe or irreversible adverse effects of Droperidol, which give rise to further complications include Tardive dyskinesia, Oculogyric crises, Laryngeal dystonias, Cardiac arrest, Acute dystonia.,Droperidol produces potentially life-threatening effects which include Arrhythmias, Neuroleptic Malignant Syndrome, Neuroleptic malignant syndrome. which are responsible for the discontinuation of Droperidol therapy.,The signs and symptoms that are produced after the acute overdosage of Droperidol include Hypotension, Cardiac arrhythmias, Convulsions, Coma, Respiratory depression, Respiratory depression, Sedation, Extrapyramidal effects, Respiratory depression.,The symptomatic adverse reactions produced by Droperidol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Sedation, Akathisia, Hypotension, Gynecomastia, Galactorrhea, Extrapyramidal effects, Dystonic reactions, HyperprolactinemiaX, Oligomenorrhea, Paradoxical effects, Blood dyscrasias, Alertness impairment, dizziness.
Precautions of Droperidol
It should be used with caution in elderly and debilitated patients because they are at an increased risk of developing adverse reactions, in patients with cardiac disease, in patients with seizure disorder or who are taking anticonvulsants, in patients with a history of phenothiazine hypersensitivity because of its structural similarities to this class of drugs. It is classified as pregnancy category C drug. It should be used with caution during pregnancy only if the potential benefit outweighs the risk to the fetus. Use with caution in women who are breast feeding. Safety in children under 2 years of age has not been established. It should not be used during procedures designed to accurately ascertain the pulmonary artery pressure because droperidol can decrease pulmonary artery pressure.