Doxepin Hcl (Doxepin Hcl)
Overview of Doxepin Hcl
Doxepin Hcl is a tricyclic antidepressant of the dibenzoxepine class, also having significant anxiolytic activity. Doxepin Hcl is effective in treating depression and to treat nerve pain, and insomnia. Two to three weeks are required to observe the full effects of drug. Doxepin Hcl is administered orally.
Indication of Doxepin Hcl
Doxepin Hcl is primarily indicated in conditions like Depressive illness, Mild anxiety, and can also be given in adjunctive therapy as an alternative drug of choice in Atopic dermatitis, Eczema, Insomnia, Lichen simplex, Migraine prophylaxis.
Contraindication of Doxepin Hcl
Doxepin (HCl) is contraindicated in conditions like Glucoma,Mania,Urinary retention.
Side Effects of Doxepin Hcl
The severe or irreversible adverse effects of Doxepin (HCl), which give rise to further complications include Heart failure.,The signs and symptoms that are produced after the acute overdosage of Doxepin (HCl) include Cardiac arrhythmias, Convulsions, Coma, Hyperthermia, Drowsiness, Blurred vision, Drowsiness, Dry mouth, Urinary retention, Respiratory depression, Respiratory depression, Mydriasis, Hypertension, Stupor, Decreased GI motility, Hyperreflexia, Respiratory depression, hyperreflexia.,The symptomatic adverse reactions produced by Doxepin (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Tachycardia, Constipation, Insomnia, Dry mouth, Blurred vision, Rashes, Confusion, Extrapyramidal reactions, Hypotension, Agitation, Psychotic symptoms, Dry mouth, Confusion, dizziness.
Precautions of Doxepin Hcl
It should be used with extreme caution in patients with a pre-existing seizure disorder because the seizure threshold may be lowered, diabetes mellitus, hepatic disease, pre-existing hematological disease, with respiratory depression, in patients with Parkinsons disease, in patients who have hyperthyroidism or are receiving thyroid drugs, with cardiac disease (because of the alterations inECG patterns). Patients with cardiovascular disease should be closely monitored and regular ECG tracings made. It should not be given to patients who are in the acute recovery phase following myocardial infarction; sudden death is possible. Therapy should be discontinued for several days prior to elective surgery because of the risk of hypertensive episodes. Patients may be more prone to sunburn during therapy with doxepin and suitable precautions should be taken (wearing long-sleeved clothing and applying sunblock). It is classified as a pregnancy category C drug. It should not be used during pregnancy, unless the possible benefits outweigh the risks to fetus. Following prolonged therapy in high doses, abrupt discontinuation of doxepin should be avoided because this can precipitate symptoms of cholinergic rebound. It should be used with caution in patients who have a history of alcoholism or who may use alcohol or other sedative medications because the depressant effects on the central nervous system can be potentiated. Bipolar disorder patients who are not concomitantly treated with an anticyclic medication are likely to switch from depression to mania, and some schizophrenic patients can experience exacerbation of psychosis.