Domperidone (Domperidone)
Overview of Domperidone
Domperidone is a dopamine blocking agent. Domperidone is antiemetic agent. Domperidone is also used to treat nausea and vomiting induced by cancer chemotherapy.
Indication of Domperidone
Domperidone is primarily indicated in conditions like Acute nausea and vomiting, Delayed gastric emptying, Dyspepsia, Functional dyspepsia, Gastric distension pain due to pressure on the stomach, Gastro-oesophageal reflux disease, Nausea and vomiting, Nausea and vomiting (chemotherapy induced), Nausea and vomiting (L-dopa induced), Non-ulcer dyspepsia, Reflux oesophagitis, and can also be given in adjunctive therapy as an alternative drug of choice in Cytotoxic chemotherapy, Heart burn, Lactation.
Contraindication of Domperidone
Domperidone is contraindicated in conditions like Allergy,Hepatic impairment,Serious resistant GI mycoses.
Side Effects of Domperidone
The severe or irreversible adverse effects of Domperidone, which give rise to further complications include Tardive dyskinesia, Parkinsonism, Extrapyramidal dystonic reactions.,Domperidone produces potentially life-threatening effects which include Seizures, Dysrhythmias. which are responsible for the discontinuation of Domperidone therapy.,The signs and symptoms that are produced after the acute overdosage of Domperidone include Convulsions, Coma, GI disturbances, Extrapyramidal effects.,The symptomatic adverse reactions produced by Domperidone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Thirst, Headache, Drowsiness, Diarrhea, Anxiety, Restlessness, Insomnia, Nervousness, Skin rashes, Dry mouth, Itching, Galactorrhea, Breast enlargement, Soreness, Hyperprolactinemia, nervousness, Reduced libido.
Precautions of Domperidone
Domperidone should be used with great caution if given intravaneously, because of the risk of arrhythmias, especially to patients predisposed to cardiac arrhythmias or hypokalaemia.