Distigmine Br (Distigmine Br)
Overview of Distigmine Br
Distigmine (Br) used in the prevention and treatment of post-operative gastro-intestinal atony and in post-operative urinary retention. Anti biotic (aunoglycoside,tetracycling,polymycin)
Indication of Distigmine Br
Distigmine Br is primarily indicated in conditions like Intestinal atony, Neurogenic bladder, Postoperative ileus, Postoperative urinary retention, Prophylaxis of NSAID-associated gastric or duodenal ulcer, and can also be given in adjunctive therapy as an alternative drug of choice in Extravasation/haematoma, Myasthenia gravis.
Contraindication of Distigmine Br
Distigmine (Br) is contraindicated in conditions like Circulatory insufficiency,GI obstruction,Urinary outflow obstruction.
Side Effects of Distigmine Br
The severe or irreversible adverse effects of Distigmine (Br), which give rise to further complications include Bronchospasm, AV-block, Sinus bradycardia, Dyspnea, Cholinergic crises.,Distigmine (Br) produces potentially life-threatening effects which include Coma, Bradycardia, Convulsions, Neuromuscular blockage, Hypotension, Hypoxemia, Paralysis, Bronchoconstriction, Severe muscle weakness. which are responsible for the discontinuation of Distigmine (Br) therapy.,The signs and symptoms that are produced after the acute overdosage of Distigmine (Br) include Nausea, Sweating, Increased peristalsis, Pallor, Retching, Spasticity, Paralysis.,The symptomatic adverse reactions produced by Distigmine (Br) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Abdominal cramps, SweatingX, Miosis, Salivation, Urinary urgency.
Precautions of Distigmine Br
Distigmine should be used with caution in patients with asthma, seizure disorder, epilepsy, heart disease such as hypertension, bradycardia, recent myocardial infraction, thyroid disorders, intestinal disorders, ulcers, urinary problems or if have any allergy especially to bromides. Large dose by mouth should be avoided in condition where there may be increase absorption from the gastrointestinal tract. It should be used only if clearly needed during pregnancy.