TIGECYCLINE (TIGECYCLINE)
Overview of TIGECYCLINE
Tigecycline is a broad-spectrum glycylcycline antibiotic derived from tetracycline. Tigecycline binds to the 30S ribosomal subunit, thereby interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This prevents the incorporation of amino acid residues into the elongating peptide chain, inhibiting protein synthesis and eventually bacterial cell growth.
Indication of TIGECYCLINE
TIGECYCLINE is primarily indicated in conditions like Infections, and can also be given in adjunctive therapy as an alternative drug of choice in Abdominal infection, Skin infections.
Contraindication of TIGECYCLINE
No data regarding the contra indications of TIGECYCLINE is available.
Side Effects of TIGECYCLINE
The signs and symptoms that are produced after the acute overdosage of TIGECYCLINE include Dizziness, Headache, Cough.
Precautions of TIGECYCLINE
Tetracycline drugs such as tigecycline may rarely cause a serious increase in pressure inside the skull (intracranial hypertension-IH). The risk of this side effect is greater for women of childbearing age who are overweight or who have had IH in the past. If IH develops, it usually goes away after tigecycline is stopped; however, there is a chance of permanent vision loss or blindness. Get medical help right away if you have: persistent/severe headache, vision changes (such as blurred/double vision, decreased vision, sudden blindness), persistent nausea/vomiting. This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a resistant bacteria. This condition may occur weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, or blood/mucus in your stool. Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection (oral or vaginal fungal infection). Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge or other new symptoms. Avoid exposure to sunlight or tanning beds. Tigecycline can make you sunburn more easily. about using a non hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using tigecycline. You should not use this medication if you are allergic to tigecycline. Children should not use tigecycline. Tigecycline can cause permanent yellowing or graying of the teeth in children younger than 8 years old