Sofosbuvir (Sofosbuvir)
Overview of Sofosbuvir
Sofosbuvir is a hepatitis C virus (HCV) nucleotide analog NS5B polymerase inhibitor indicated for the treatment of chronic hepatitis C (CHC) infection as a component of a combination antiviral treatment regimen SOfosbuvir efficacy has been established in subjects with HCV genotype 1, 2,3 or 4 infection, including those with hepatocellular carcinoma meeting Milan criteria (awaiting liver transplantation) and those with HCV/HIV-1 co-infection. The IUPAC name for sofosbuvir is (S)-Isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo�3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2�yl)methoxy)-(phenoxy)phosphorylamino)propanoate.
Indication of Sofosbuvir
Sofosbuvir is primarily indicated in conditions like Chronic hepatitis C.
Contraindication of Sofosbuvir
No data regarding the contra indications of Sofosbuvir is available.
Side Effects of Sofosbuvir
No data regarding the side effects produced by Sofosbuvir is available
Precautions of Sofosbuvir
Pregnancy: sofosbuvir in combination with Ribavirin may cause birth defects and fetal death and animal studies have shown interferons have abortifacient effects;avoid pregnancy in female patients and female partners of malepatients. Patients must have a negative pregnancy test prior toinitiating therapy, use at least 2 effective non-hormonal methods of contraception and have monthly pregnancy tests