Mipomersen Sodium (Mipomersen Sodium)
Overview of Mipomersen Sodium
Mipomersen sodium is an oligonucleotide inhibitor of apo B-100 synthesis. ApoB is the principal apolipoprotein of LDL and its metabolic precursor, very low density lipoprotei (VLDL). Mipomersen inhibits synthesis of apoB by sequence-specific binding to its messenger ribonucleic acid (mRNA) resulting in degradation of the mRNA through enzyme-mediated pathways or disruption of mRNA function through binding alone. It is used as adjunct to lipid lowering medications and diet to reduced low density lipoprotein cholestrol(LDL C) Apolipoprotein B, total cholestrol(TC) and non high density lipoproteincholestrol (Non HDL C) in patient with Homozygous Familial HyperCholesterolemia(HOFH)
Indication of Mipomersen Sodium
Mipomersen Sodium is primarily indicated in conditions like Homozygous familial hypercholesterolemia.
Contraindication of Mipomersen Sodium
No data regarding the contra indications of Mipomersen Sodium is available.
Side Effects of Mipomersen Sodium
The symptomatic adverse reactions produced by Mipomersen Sodium are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Injection site reactions, Flu like symptoms, elevation in serum transaminases.
Precautions of Mipomersen Sodium
De to risk of hepatic toxicity, before beginning treatment, measure transaminases (ALT, AST), alkaline phosphatase, and total bilirubin . injection site reactions like erythema, pain, tenderness, pruritus and local swelling, Flu-like symptoms such as influenza like illness, pyrexia, chills, myalgia, arthralgia, malaise or fatigue, which typically occur within 2 days after an injection,