Pegloticase (Pegloticase)
Overview of Pegloticase
Peglotigase which is a PEGylated uric acid specific enzyme obtained from genitically modified mammalin urate oxidase(uricase) which achieves it therapeutic effect by catalyzing the oxidation of uric acid to allantoin, thereby lowering serum uric acid.
Indication of Pegloticase
Pegloticase is primarily indicated in conditions like Asymptomatic Hyperuricemia, Gout.
Contraindication of Pegloticase
Pegloticase is contraindicated in conditions like G6pd deficiency.
Side Effects of Pegloticase
The severe or irreversible adverse effects of Pegloticase, which give rise to further complications include Congestive heart failure.,Pegloticase produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Pegloticase therapy.,The symptomatic adverse reactions produced by Pegloticase are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dyspnea, Constipation, Urticaria, Pruritus, Erythema, Nausea and vomiting, Chest pain, Ecchymoses, Infusion reactions, 1st dose, Nasopharyngitis, gout flares, contusion.
Precautions of Pegloticase
pegloticase should be administered by a healthcare provider. patient should be pre medicated with Antihistamines and Cortico steroids. Patient should be closely monitored for Anaphylaxis. Monitor Serum Uric Acid level prior to infusion , Discontinue treatment if level increase to above 6mg/dl. monitor closely for sign and symptoms of infusion reaction. Excercise caution in patient who have Congestive heart failure.