Dalfampridine (Dalfampridine)
Overview of Dalfampridine
Dalfampridine (4-amino pyridine) is used to improve walking in patients with multiple sclerosis. It acts by blocking potassium channels due to which conduction in focally demyelinated axons is increased because of which it enhances muscle contraction and thereby improves walking in patients
Indication of Dalfampridine
Dalfampridine is primarily indicated in conditions like Multiple sclerosis.
Contraindication of Dalfampridine
Dalfampridine is contraindicated in conditions like Seizures,Renal impairment.
Side Effects of Dalfampridine
The severe or irreversible adverse effects of Dalfampridine, which give rise to further complications include Seizures, Dizziness, Urinary tract infection.,Dalfampridine produces potentially life-threatening effects which include Seizures, multiple sclerosis relapse. which are responsible for the discontinuation of Dalfampridine therapy.,The signs and symptoms that are produced after the acute overdosage of Dalfampridine include Confusion, hypophonic speech, Temporal lobe hyperintensities, Weakness, reduced awareness, altered mental state, complex partial seizures, memory loss.,The symptomatic adverse reactions produced by Dalfampridine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Ataxia, Nausea, Constipation, Insomnia, Confusion, Dyspepsia, Asthenia, Visual disturbances, Back pain, Nasopharyngitis, balance disorder, pharyngolaryngeal pain, parasthesia.
Precautions of Dalfampridine
do not administer dalfampridine in patients with seizures, ,renally impaired patients ,concurrent treatment with other forms of 4-Amino pyridine and in urinary tract infections