Doxofylline (Doxofylline)
Overview of Doxofylline
Doxofylline (7-(1,3-dioxalan-2-ylmethyl) theophylline) is a novel xanthine bronchodilator which vary from theophylline in that it contains a dioxalane group in position 7. Similarly to theophylline, its mechanism of action is associated to the inhibition of phosphodiesterase behavior. Doxofylline is shown to have similar efficacy with notably less adverse effects in both animal studies as well as human adults. However, there is a lack of studies in children with asthma. Retrospective data imply that 11% patients experienced some adverse effects, but only 5% reported moderate adverse effects.
Indication of Doxofylline
Doxofylline is primarily indicated in conditions like Bronchial asthma, Bronchospasm, Chronic asthmatic bronchitis.
Contraindication of Doxofylline
Doxofylline is contraindicated in conditions like Hypersensitivity to xanthine derivatives,Acute myocardial infarction.
Side Effects of Doxofylline
The severe or irreversible adverse effects of Doxofylline, which give rise to further complications include Seizures, Arrythmia, low blood sugar.,The signs and symptoms that are produced after the acute overdosage of Doxofylline include Convulsions, Paroxysmal spasm crises, Metabolic acidosis, Rhabdomyolysis, Arrhythmias.,The symptomatic adverse reactions produced by Doxofylline are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Irritability, Nausea, Vomiting, Tachycardia, Insomnia, Abdominal pain, Heart burn, Shortening of breath, Contractions, Proteinuria, Hyperglycemia.
Precautions of Doxofylline
Doxofylline not xanthine with other drugs taken at the same time, proposed not to drink beverages and foods containing caffeine. Adrenaline and ephedrine or other drugs necessary to be careful with clothes. To alleviate symptoms of adverse effects, may suspend medication, if necessary, medical diagnosis, but in the signs of poisoning and the symptoms disappeared completely after taking will continue. It should be given with cuation to pateints with peptic uluration hyperthycoidism, cardiac arrythmias.