Piroxicam-beta-cyclodextrin (Piroxicam-beta-cyclodextrin)
Overview of Piroxicam-beta-cyclodextrin
Piroxicam-beta-cyclodextrin is a complex of the nonsteroidal antiinflammatory drug (NSAID) piroxicam and an inert cyclic macromolecule, beta-cyclodextrin. In clinical trials in patients with pain or rheumatic diseases arising from other conditions, it was as effective an analgesic as standard piroxicam, and showed a faster onset of action on the first day of treatment. In healthy volunteers short term pharmacodynamic studies showed, piroxicam-beta-cyclodextrin was equivalent to or tended to show less gastrointestinal mucosal toxicity than standard piroxicam, as evaluated by endoscopy and faecal blood loss
Indication of Piroxicam-beta-cyclodextrin
Piroxicam-beta-cyclodextrin is primarily indicated in conditions like Acute gout, Acute musculoskeletal disorders, Acute pain, Ankylosing spondylitis, Backache, Dysmenorrhoea, Juvenile chronic arthritis, Migraine, Osteoarthritis, Post operative pain, Rheumatic diseases, and can also be given in adjunctive therapy as an alternative drug of choice in Juvenile rheumatoid arthritis.
Contraindication of Piroxicam-beta-cyclodextrin
Piroxicam-beta-cyclodextrin is contraindicated in conditions like Asthma,Peptic ulcer,Thrombosis,Rhinitis,Urticaria,Impaired hepatic function,Angioedema,Hypersensitivity.
Side Effects of Piroxicam-beta-cyclodextrin
The severe or irreversible adverse effects of Piroxicam-beta-cyclodextrin, which give rise to further complications include Skin reactions, Erythema, Interstitial nephritis.,Piroxicam-beta-cyclodextrin produces potentially life-threatening effects which include GI bleeding, Aplastic Anemia, Renal damage, Peptic ulceration, Purpura, Pemphigus vulagris. which are responsible for the discontinuation of Piroxicam-beta-cyclodextrin therapy.,The signs and symptoms that are produced after the acute overdosage of Piroxicam-beta-cyclodextrin include Nausea, Vomiting, Diarrhea, Convulsions, Coma, Hematuria, Acute renal failure, Dizziness, Headache, Hyperventilation, Rashes, Proteinuria, Hyperreflexia, Tinnitus, Hypoprothrombinemia, GI bleeding, hyper reflexia.,The symptomatic adverse reactions produced by Piroxicam-beta-cyclodextrin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Skin irritation, Nausea and vomiting, Edema, GI disturbance, Erythema multiforme, Azotemia, bronchoconstriction.
Precautions of Piroxicam-beta-cyclodextrin
Piroxicam should be used with caution in patients with intrinsic coagulation defects and those on anticoagulant therapy. It should be used with caution in patients with compromised cardiac function, hypertension other condition predisposing to fluid retention. Discontinue drug if skin reaction occurs. It should be used with extra care in the presence of existing controlled infection.