Mesoridazine Besylate (Mesoridazine Besylate)
Overview of Mesoridazine Besylate
Mesoridazine besylate, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer which is effective in the treatment of schizophrenia, organic brain disorders, alcoholism and psychoneuroses. Mesoridazine besylate is 10 [2(1-methyl 2-piperidyl) ethyl]-2-(methyl-sulfinyl)-phenothiazine [as the besylate].
Indication of Mesoridazine Besylate
Mesoridazine Besylate is primarily indicated in conditions like Schizophrenia, and can also be given in adjunctive therapy as an alternative drug of choice in Chronic alcoholism, Hyperactivity.
Contraindication of Mesoridazine Besylate
Mesoridazine Besylate is contraindicated in conditions like CNS depression,Hypersensitivity to the drug.
Side Effects of Mesoridazine Besylate
Mesoridazine Besylate produces potentially life-threatening effects which include Arrhythmias. which are responsible for the discontinuation of Mesoridazine Besylate therapy.,The signs and symptoms that are produced after the acute overdosage of Mesoridazine Besylate include Vomiting, Edema, Tachycardia, Coma, Dilated pupils, Ataxia, Tremor, Agitation, Congestive heart failure, Dystonia.,The symptomatic adverse reactions produced by Mesoridazine Besylate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Drowsiness, Vomiting, Constipation, Dry mouth, Hypotension.
Precautions of Mesoridazine Besylate
While ocular changes have not to date been related to Mesoridazine besylate, one should be aware that such changes have been seen with other drugs of this class. Because of ponoible hypotensive effects, reserve parenteral administration for bedfast patients or for acute ambulatory cases, and keep patient lying down for at least one-half hour after injection. Leokopenia and/or agranulocytosis have been attributed to phenothiazine therapy. A single case of transient granulocytopenia has been associated with mesoridazine besylate. Since convulsive seizures have been reported, patients receiving anticonvulsant medication should be maintained on that regimen while receiving mesoridazine besylate.