Cyanocobalamin (Cyanocobalamin)
Overview of Cyanocobalamin
Cyanocobalamin is also called vitamin B12. It is the most recently discovered of the viatmin B series, was isolated from the liver fraction in 1948. Cyanocobalamin is a complex water soluble compound. It is made up of a porphyrin like ring with a central cobalt atom attached to a nucleotide. It is required in body for growth, cell production and for blood and nerve function. The source of vitamin B12 is microbial synthesis, it is not present in plants or cereal grains to a measurable extent. The chief dietary source is microbially derived vitamin B12 in meat, eggs and dairy products. Humans must obtain the vitamin from the dietary intake of animal products.
Indication of Cyanocobalamin
Cyanocobalamin is primarily indicated in conditions like Addisonian pernicious anaemia, Congenital cobalamine malabsorption, Congenital intrinsic factor deficiency, Homocystenemia, Ileal resection, Methylmalonylacidurias, Nutrition deficiency, Post gastrectomy vit B-12 deficiency, Transcobalamin II deficiency, and can also be given in adjunctive therapy as an alternative drug of choice in Infestations, Malignancy, Tapeworm infection, Vitamin-B12 defeciency of dietary origin.
Contraindication of Cyanocobalamin
Cyanocobalamin is contraindicated in conditions like Anaphylactic reactions,Tobacco amblyopia.
Side Effects of Cyanocobalamin
The severe or irreversible adverse effects of Cyanocobalamin, which give rise to further complications include Congestive heart failure, Pulmonary edema, Thrombosis, Peripheral vascular disease.,Cyanocobalamin produces potentially life-threatening effects which include Hypersensitivity reactions, Shivering, Bronchospasm, Dyspnea, Persistant urticaria, Bronchospasm. which are responsible for the discontinuation of Cyanocobalamin therapy.,The symptomatic adverse reactions produced by Cyanocobalamin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Itching, Eczematous skin reaction.
Precautions of Cyanocobalamin
Cyanocobolamine should be used with caution in patients with suspected cobalt hypersensitivity, any pre-existing illnesses or any allergy. This medication should be used only as directed during pregnancy or lactation.