Lomustine (Lomustine)
Overview of Lomustine
LOMUSTINE is a type of chemotherapy for treating cancer. Lomustine belongs to a group of medicines known as alkylating agents. Lomustine interferes with cell growth and is used to treat brain tumors and certain cancers of the blood (Hodgkin's disease). Generic lomustine capsules are not yet available.
Indication of Lomustine
Lomustine is primarily indicated in conditions like Brain tumors, Hodgkin's disease, and can also be given in adjunctive therapy as an alternative drug of choice in Breast cancer, Lung cancer, Multiple myeloma, Non-hodgkin's lymphoma, Non-hodgkin's lymphoma, Ovarian cancer, Pancreatic cancer, Renal carcinoma.
Contraindication of Lomustine
Lomustine is contraindicated in conditions like Hypersensitivity to any component of product.
Side Effects of Lomustine
The severe or irreversible adverse effects of Lomustine, which give rise to further complications include Pregnancy.,The signs and symptoms that are produced after the acute overdosage of Lomustine include Hypoxaemia, Yellow skin, Sore throat, Liver dysfunction, Bruising, Pulmonary toxicity.,The symptomatic adverse reactions produced by Lomustine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Confusion, Lethargy, Hair loss, Nausea and vomiting, Loss of appetite, Confusion, Mouth sores.
Precautions of Lomustine
Since the major toxicity is delayed bone marrow suppression, blood counts should be monitored weekly for at least 6 weeks after a dose. Liver and renal function tests should be monitored periodically. For all instances where the use of lomustine is considered for chemotherapy, the physician must evaluate the need and usefulness of the drug against the risks of toxic effects or adverse reactions. Reinstitution of lomustine therapy should be carried out with caution, and with adequate consideration of the further need for the drug and alertness as to possible recurrence of toxicity.