methoxyflurane (methoxyflurane)
Overview of methoxyflurane
Methoxyflurane is a general inhalation anesthetic used for the induction and maintainence of general anesthesia.It induces muscle relaxation and reduces pain sensitivity by altering tissues excitibilty.It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels.
Indication of methoxyflurane
methoxyflurane is primarily indicated in conditions like Labor pains, Pain in short surgical procedure., Trauma.
Contraindication of methoxyflurane
methoxyflurane is contraindicated in conditions like Respiratory depression,Cardiovascular disease,Unconciousness,Head injury,Hypersensitivity.
Side Effects of methoxyflurane
The severe or irreversible adverse effects of methoxyflurane, which give rise to further complications include Nephrotoxicity, Renal failure, Increased serum creatinine, Laryngospasm, Oxaluria.,The signs and symptoms that are produced after the acute overdosage of methoxyflurane include Bradycardia, Hypotension, Respiratory depression, Respiratory depression, Cardiac arrest, Respiratory depression, Malignant hyperthermia.,The symptomatic adverse reactions produced by methoxyflurane are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Drowsiness, Nausea, Vomiting, Fever, Coughing, Polyuria, dizziness.
Precautions of methoxyflurane
Caution should be exercised in the following circumstances due to the possibility of increased free flouride and oxalic acid levels .1.Reduced GFR or urine output.2.Reduced renal blood flow.