Mafenide Acetate (Mafenide Acetate)
Overview of Mafenide Acetate
Mafenide Acetate is an antibacterial, belongs to sulphonamides. Mafenide Acetate is used topically to prevent bacterial colonisation and infection of burn wounds. Mefenide acetate is absorbed from burn sites, and systemic levels are produced. The drug and its metabolites cause metabolic acidosis, a side effect that limits its usefulness.
Indication of Mafenide Acetate
Mafenide Acetate is primarily indicated in conditions like Bacterial infections, Burns.
Contraindication of Mafenide Acetate
Mafenide Acetate is contraindicated in conditions like Hypersensitivity to any component of product.
Side Effects of Mafenide Acetate
Mafenide Acetate produces potentially life-threatening effects which include Hynolytic Anaemia. which are responsible for the discontinuation of Mafenide Acetate therapy.,The symptomatic adverse reactions produced by Mafenide Acetate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Allergic reactions, Hyperventilation, Metabolic acidosis, Urinary alkalosis, Intense pain at sites of application, Loss of fluid by evaporation from the burn surface.
Precautions of Mafenide Acetate
Since occlusive dressings are not used. The drug and its primary metabolite inhibit Carbonis Anhydrase, and the urine becomes alkaline.A metabolic acidosis with compensatory tachypnea and hyperventilation may ensue and has limited the usefulness of mafenide.