Sodium Biphosphate (Sodium Biphosphate)
Overview of Sodium Biphosphate
Sodium Biphosphate is used in the management of hypophosphatemia caused by phosphate deficiency or hypophosphatemic states. Sodium Biphosphate is usually given orally, intravenous route is seldom necessary. It has also been employed for the prophylaxis of calcium renal calculi.
Indication of Sodium Biphosphate
Sodium Biphosphate is primarily indicated in conditions like Analgesia and suppression of respiratory activity, Analgesia during operation, enhancement of anaesthesia, Hypercalcaemia.
Contraindication of Sodium Biphosphate
Sodium Biphosphate is contraindicated in conditions like Hypersensitivity to any component of product.
Side Effects of Sodium Biphosphate
The symptomatic adverse reactions produced by Sodium Biphosphate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Hypocalcemia, Hyperphosphatemia, Electrolyte imbalance.
Precautions of Sodium Biphosphate
Phosphate should not generally be administered to patients with severe renal impairment. They should be avoided in patients who may have low-serum concentrations, as these may be decrease further, and in patients with infected phosphate renal calculi. Sodium Phosphate should generally be avoided in patients with congestive heart faliure (CHF), hypertension, and oedema. Serum electrolyte and renal function should be monitored during therapy, particularly if phosphates are administered parenterally. Oral or rectal sodium phosphate preparation should not be used in patients with gastro-intestinal obstruction, inflammatory bowel disease, and conditions where there is likely to be increased colonic absorption. They should be used with caution in elderly and debilitated patients, and in those with pre-existing electrolyte disturbances.