Deflazacort (Deflazacort)
Overview of Deflazacort
Deflazacort is a corticosteroid with mainly glucocorticocoid activity. The uses and actions are similar to those of prednisolone.
Indication of Deflazacort
Deflazacort is primarily indicated in conditions like Inflammation, Status epilepticus (unlicensed use).
Contraindication of Deflazacort
Deflazacort is contraindicated in conditions like Mild or moderate typhoid due to multiple antibacterial-resistant organisms,Tuberculosis resistant to first line drugs.
Side Effects of Deflazacort
The severe or irreversible adverse effects of Deflazacort, which give rise to further complications include Thromboembolism.,The symptomatic adverse reactions produced by Deflazacort are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Insomnia, Dyspepsia, Malaise, Depression, Weight gain, Candidiasis, Psychosis, Bruising, Acne, Increased appetite, Euphoria, Menstrual irregularity, Amenorrhea, Cushing syndrome, Proximal myopathy, Acute pancreatitis, Esophageal ulceration, GI disturbance, Glaucoma, Skin atrophy, Hiccups, Bruising, Peptic ulcer, Abnormal distension, Oesteoporosis, Psychological dependence, Impaired skin, Skin Atrophy, dyspepsia, Musculoskeletal Endocrine, Ophthalmic and Electrolyte disturbances.
Precautions of Deflazacort
Deflazacort should be used with caution in patients with adrenal supression and infection (prolong course of corticosteroid increase susceptibility to infection and severity of infection; clinical presentation of infection may also be atypical); children and adolescents (growth retardation possibly irreversible), elderly (close supervision required perticularly on long-term treatment); frequent monitoring required if history of tuberculosis (or X-ray changes), hypertension, recent myocardial infarction (rupture reported), congestive heart failure, liver failure, renal impairment, diabetes mellitus including family history, osteoporosis (post-menopausal women at special risk), glaucoma (including family history), severe effective disorders (perticularly if history of steroid-induced psychosis), epilepsy, peptic ulcer, hypothyroidism, history of steroid myopathy; pregnancy, pregnancy and breast-feeding.