Clofibrate (Clofibrate)
Overview of Clofibrate
Clofibrate is antihyperlipidimic agent. Chemically Clofibrate is ethyl 2-(p-chlorophenoxy)-2 methylpropionate. It reduces the high blood cholesterol level.
Indication of Clofibrate
Clofibrate is primarily indicated in conditions like Hypercholesterolaemia, Hyperlipidaemia, Hyperlipidemia, Hyperlipoproteinaemia.
Contraindication of Clofibrate
Clofibrate is contraindicated in conditions like Gall stones,Impaired hepatic function,Hypoalbuminaemia,Impaired renal function,Gall bladder disease.
Side Effects of Clofibrate
The severe or irreversible adverse effects of Clofibrate, which give rise to further complications include Diarrhoea, Impotence, Gall stones.,Clofibrate produces potentially life-threatening effects which include Cardiac arrhythmias, Cholisthiasis, Thromboembolic disorders, Cholestasis. which are responsible for the discontinuation of Clofibrate therapy.,The symptomatic adverse reactions produced by Clofibrate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Nausea, Vomiting, Alopecia, Alopecia.
Precautions of Clofibrate
Withdraw the drug after 3 months if adequate response is not achieved. It should be used with caution in patients with history of liver disease, jaundice or peptic ulcer. Perform complete blood count periodically because anemia and leukopenia have been reported in patients taking clofibrate.