Amprenavir (Amprenavir)
Overview of Amprenavir
Amprenavir is an antiviral agent, active against HIV infection. It belongs to protease inhibitors. Amprenavir is used in combination with other antiretroviral drugs in the treatement of HIV infection and AIDS.
Indication of Amprenavir
Amprenavir is primarily indicated in conditions like Gastric acid reduction during anaesthesia, HIV infection in combination with other antiretroviral drugs.
Contraindication of Amprenavir
Amprenavir is contraindicated in conditions like Pregnancy,Liver damage,Kidney disease,Breast feeding.
Side Effects of Amprenavir
The symptomatic adverse reactions produced by Amprenavir are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Dizziness, Headache, Fatigue, Diarrhea, Abdominal pain, Rashes, Pruritus, Hypotension, Depression, Nausea and vomiting, Hypersensitivity reactions, GI disturbance, Blood disorders including anemia, and neutropenia.
Precautions of Amprenavir
Amprenavir should be used with caution in patients with hepatic impairment (May need dose reduction); pregnancy (use only if potential benefit outweighs risk); diabetes; haemophilia; avoid vitaminE suppliments (vit.E included in formulation); oral solution contains propylene glycol----avoid in hepatic impairment, in severe renal impairment, in pregnancy, and avoid concomitant metronidazole, disulfiram, or preparation containing alcohol or propylene glycol; increased susceptibility to propylene glycol toxicity in slow metaboliser.RASH: Rash may occur, usually in the second week of therapy; discontinue permanently if severe rash with systemic or allergic symptoms or, mucosal involvement; if rash mild or moderate, may continue without interruption----rash usally resolves within two weeks and may respond to antihistamines.