Telithromycin (Telithromycin)
Overview of Telithromycin
A derivative of erythromycin, antibacterial spectrum of telithromycin is similar to that of macrolides and it is also active against penicillin- and erythromycin-resistant Streptococcus pneumoniae. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed .It is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.
Indication of Telithromycin
Telithromycin is primarily indicated in conditions like Prevention of relapse in duodenal ulcer, Sedation in intensive care, Severe or recurrent duodenal and gastric ulcertion, Sinusitis, Tonsillitis.
Contraindication of Telithromycin
Telithromycin is contraindicated in conditions like Breast feeding.
Side Effects of Telithromycin
The symptomatic adverse reactions produced by Telithromycin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Anorexia, Diarrhea, Palpitation, Constipation, Insomnia, Abdominal pain, Blurred vision, Pruritus, Hypotension, Nausea and vomiting, Muscle cramps, Facial edema, Paresthesia/hyperesthesia, Eosinophilia, Antibiotic-associated colitis, Arrhythmia.
Precautions of Telithromycin
Telithromycin should be used with caution in hepatic impairment; renal impairment (use half normal dose if creatinine clearance less than 30ml/min); pregnancy (use only if potential benefit outweighs risk); coronary heart disease, ventricular arrhythmias, brady cardia, hypokalaemia, hypomagnesaemia, risk of QT interval prolongation; cocumitant adminstration of drug that prolong QT interval. Arrhythmias: Avoid cocomitant adminstration with pimozide or terfenadine.