Alteplase (Alteplase)
Overview of Alteplase
Alteplase is a fibrinolytic agent. Alteplase is a tissue plasminogen activator (t-PA) produced by recombinant DNA technology. It works to break up and dissolve blood clots which can block arteries. I is usde in fibrinolytic therapy of acute heart attack or pulmonary embolism and ischemic stroke. Alteplase is better than streptokinase and urokinase in dissolving older clots.
Indication of Alteplase
Alteplase is primarily indicated in conditions like Acute ischaemic stroke, Myocardial infarction, Peripheral arterial thrombosis, Peripheral venousthrombosis, Pulmonary embolism, Stroke.
Contraindication of Alteplase
Alteplase is contraindicated in conditions like Peptic ulcer,Recent surgery or trauma,Susceptibility to internal bleeding,Menstruation.
Side Effects of Alteplase
The severe or irreversible adverse effects of Alteplase, which give rise to further complications include Urinary tract bleeding, Gingival tissue bleeding.,Alteplase produces potentially life-threatening effects which include Hemorrhage, Hemorrhage. which are responsible for the discontinuation of Alteplase therapy.,The signs and symptoms that are produced after the acute overdosage of Alteplase include Bleeding.,The symptomatic adverse reactions produced by Alteplase are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vomiting, Hypotension, Hypersensitivity reactions.
Precautions of Alteplase
Alteplase should be used with caution in patients with major surgry, organ biopsy or trauma within the past 10 days, cardiovascular disease, pregnancy, diabetic retinopathy. It should be used with extreme caution in conditions in which bleeding could be hazardous or difficult to control due to its location. If anaphylactic reaction occur during therapy, discontinue the infusion and manage the conditions accordingly. It is not recommended for patients over 80 years.