Naratriptan (Naratriptan)
Overview of Naratriptan
Naratriptan is a selective serotonin (5HT-1) agonist, similar to sumatriptan. Naratriptan is given orally only in the treatment of acute migraine attacks, it should not be used for the prophylaxis of migraine. It may be used during the established headache phase of an attack and is the preferred treatment in those who fail to respond to conventiaonal therapy.
Indication of Naratriptan
Naratriptan is primarily indicated in conditions like Migraine.
Contraindication of Naratriptan
Naratriptan is contraindicated in conditions like Peripheral vascular disease,Ischaemic heart disease,Uncontrolled hypertension,Adjunct in treatment of opioid dependance,Chronic intractable hypoglycaemia.
Side Effects of Naratriptan
The symptomatic adverse reactions produced by Naratriptan are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Fatigue, Dysuria, Flushing, Nausea and vomiting, Tingling, Heaviness, Tightness of any part of body, Bradycardia or tachycardia.
Precautions of Naratriptan
5HT1 agonists (e.g Naratriptan) should be used with caution in conditions which predispose to coronary artery disease (pre-existing cardiac disease), pregnancy and breast-feeding. 5HT1 agonists are recommended as monotherapy and should not be taken concurrently with other acute migraine therapies. Little information is available on the use of these drugs in the elderly (over 65 year). Caution is also required in mild or moderate hepatic impairment; sensitivity to sulphonamides.