Danaparoid Sodium (Danaparoid Sodium)
Overview of Danaparoid Sodium
Danaparoid Sodium is a heparinoid representing a mixture of low-molecular weight sulfated glycosaminoglycans: heparan (not heparin) sulfate (84%), dermatan sulfate (12%), and chondroitin sulfate (4%). Danaparoid is obtained from porcine intestinal mucosa after the removal of heparin. The mean molecular weight of danaparoid is 5500 daltons. Danaparoid Sodium is used for prophylaxis of deep-vein thrombosis in patients undergoing general or orthopaedic surgery, and in the management of thromboembolic disease in patients with history of heparin-induced thrombocytopenia.
Indication of Danaparoid Sodium
Danaparoid Sodium is primarily indicated in conditions like Endometrial thinning before intra-uterine surgery, Prophylaxis of venous thromboembolism.
Contraindication of Danaparoid Sodium
Danaparoid Sodium is contraindicated in conditions like Peptic ulcer,Traumatic injury,Acute musculoskeletal disorders,Relief of sore throat,Initial treatment of acute conditions,Pain management,General dose,Following coronary bypass surgery.
Side Effects of Danaparoid Sodium
The symptomatic adverse reactions produced by Danaparoid Sodium are more or less tolerable and if they become severe, they can be treated symptomatically, these include Hypersensitivity reactions, Thrombocytopenia, Hemorrhage, Bruising or pain at injection site.
Precautions of Danaparoid Sodium
Hepatic and renal impairment (avoid for prophylaxis if severe); pregnancy and breast-feeding. Presence of sulphite in ampoules may (especially in patients with asthma) lead to hypersensitivity (with bronchospasm and shock)