Rosuvastatin (Rosuvastatin)
Overview of Rosuvastatin
Rosuvastatin is a lipid regulating drug, belongs to statins. Rosuvastatin is a selective, competitive inhibitor of HMG-CoA reductase, an enzyme involved in the synthesis of cholesterol in the liver. Rosuvastatin is used in the treatment of primary hypercholesterolaemia, mixed dyslipidaemias or homozygous familial hypercholesterolaemia in patients who have not responded adequately to diet and other appropriate measures. Statins are more effective than other classes in lowering the LDL-cholesterol, they reduce coronary events, all cardiovascular events, and total mortality.
Indication of Rosuvastatin
Rosuvastatin is primarily indicated in conditions like Hypercholesterolaemia, Hyperlipidaemia, and can also be given in adjunctive therapy as an alternative drug of choice in Hypertriglyceridaemia.
Contraindication of Rosuvastatin
Rosuvastatin is contraindicated in conditions like Liver diseases,Renal impairment,Pregnancy,Lactation,Hypersensitivity to any component of product.
Side Effects of Rosuvastatin
Rosuvastatin produces potentially life-threatening effects which include Abdominal pain, Myalgia. which are responsible for the discontinuation of Rosuvastatin therapy.,The symptomatic adverse reactions produced by Rosuvastatin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Asthenia, Hypersensitivity, Pancreatitis.
Precautions of Rosuvastatin
Rosuvastatin therapy should be discontinued if markedly elevated creatinine kinase levels occur or myopathy is diagnosed or suspected. Rosuvastatin therapy should also be temporarily withheld in any patient with an acute, serious condition suggestive of myopathy or predisposing to the development of renal failure secondary to rhabdomyolysis.Should be used with caution in patients who consume substantial quantities of alcohol and/or have a history of chronic liver disease