Lepirudin (Lepirudin)
Overview of Lepirudin
Lepirudin is a recombinant hirudin which is used as anticoaggulant in patients with heparin-induced thrombocytopenia who require parenteral antithrombotic treatment. Lepirudin is being invastigated in arterial thrombo-embolic disorders such as angina and MI (myocardial infarction).
Indication of Lepirudin
Lepirudin is primarily indicated in conditions like Endometrial thinning before intra-uterine surgery.
Contraindication of Lepirudin
Lepirudin is contraindicated in conditions like Pregnancy,Breast feeding.
Side Effects of Lepirudin
The severe or irreversible adverse effects of Lepirudin, which give rise to further complications include Bleeding, Hematoma, Hematoma, Hypersensitivity.,Lepirudin produces potentially life-threatening effects which include Intracranial hemorrhages. which are responsible for the discontinuation of Lepirudin therapy.,The signs and symptoms that are produced after the acute overdosage of Lepirudin include Bleeding complications.,The symptomatic adverse reactions produced by Lepirudin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Fever, Hematuria, Allergic reactions, Rectal bleeding, Anemia.
Precautions of Lepirudin
Renal impairment; hepatic impairment; recent bleeding or risk of bleeding including recent puncture of large vessels, organ biopsy, recent major surgery, stroke, haemorrhagic diathesis, severe uncontrolled hypertension, bacterial endocarditis; determine activated partial thromboplastin time 4 hrs after start of treatment (or after infusion rate altered) and at least once daily thereafter.