Pioglitazone (Pioglitazone)
Overview of Pioglitazone
Pioglitazone is a thiazolidinedione antidiabetic, reduces peripheral insulin resistance resulting in a reduction in blood-glucose concentration. Pioglitazone is used, either alone or in combination with metformin or sulphonylureas for the management of type II diabetes mellitus.
Indication of Pioglitazone
Pioglitazone is primarily indicated in conditions like Diabetes mellitus type-ii, Softening and dilatation of cervix before mechanical cervical dilatation, Type II diabetes mellitus.
Contraindication of Pioglitazone
Pioglitazone is contraindicated in conditions like Cardiac failure,Hepatic impairment,Hypersensitivity to the drug,In combination with insulin,History of cardiac failure.
Side Effects of Pioglitazone
The severe or irreversible adverse effects of Pioglitazone, which give rise to further complications include Jaundice.,The symptomatic adverse reactions produced by Pioglitazone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Myalgia, Pharyngitis, Sinusitis.
Precautions of Pioglitazone
Monitor liver function (Rare reports of liver dysfunction; monitor liver function before treatment, then every 2 months for 12 months and periodically thereafter; ask patient to immediately get medical attention if symptoms such as nausea, vomiting, abdominal pain, fatigue and dark urine develop; discontinue if jaundice occurs. Cardiovascular disease (risk of heart failure)