MethotrimeprazineHcl (MethotrimeprazineHcl)
Overview of MethotrimeprazineHcl
MethotrimeprazineHcl is phenothiazine with actions and pharmacological properties similar to that of both clorpromazine and promethazine. MethotrimeprazineHcl is used intramuscularly (IM), in the treatment of various psychoses including schizopherenia, as an adjunct to analgesics in the management of severe terminal pain. Methotrimeprazine Hcl is also used as a premedicant and is given prior to surgical procedures.
Indication of MethotrimeprazineHcl
MethotrimeprazineHcl is primarily indicated in conditions like Anxiety, Moderate to severe pain, Psychosis, Schizophrenia.
Contraindication of MethotrimeprazineHcl
Methotrimeprazine(HCl) is contraindicated in conditions like Bone marrow depression,Coma,Heart disease,Close-angle glaucoma.
Side Effects of MethotrimeprazineHcl
The severe or irreversible adverse effects of Methotrimeprazine(HCl), which give rise to further complications include Tardive dyskinesia, Paralytic ileus, Seizures, Lens opacities, Maculopathy, Respiratory distress.,Methotrimeprazine(HCl) produces potentially life-threatening effects which include Agranulocytosis, Malignant neuroplastic syndrome. which are responsible for the discontinuation of Methotrimeprazine(HCl) therapy.,The signs and symptoms that are produced after the acute overdosage of Methotrimeprazine(HCl) include Hypotension, Tachycardia, ECG alterations, Drowsiness, Hypothermia, Ventricular arrhythmias, Severe extrapyramidal dyskinesias, Loss of conciousness.,The symptomatic adverse reactions produced by Methotrimeprazine(HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dry mouth, Sedation, Photosensitivity, Parkinsonism, Hypotension, Weight gain, Asthenia, Contact dermatitis, Erythematous rash.
Precautions of MethotrimeprazineHcl
Methotrimeprazine should be used in low initial dose. Monitor pulse and blood pressure until dosage requirements and responses are stabilized in elderly and debilitated patients.