Cimetidine Hcl (Cimetidine Hcl)
Overview of Cimetidine Hcl
Cimetidine Hcl is a histamine H2 receptor blocking agent. It conatins a substituted imidazole ring. Cimetidine approved for clinical use in 1977 by the Food and Drug Aministration and after five years of clinical experience of cimetidine in 25 million patients, cimetidine is considered the prototype drug for ulcer therapy.
Indication of Cimetidine Hcl
Cimetidine Hcl is primarily indicated in conditions like Acid-related dyspepsia, Aspiration prophylaxis, Benign gastric and duodenal ulceration, Degradation of pancreatic enzyme suppliments, Duodenal ulcer, Dyspepsia, Gastric acid reduction (surgical procedures), Gastric ulceration, Mendelsons syndrome prophylaxis, NSAID associated ulceration, NSAID-induced ulcer prophylaxis, Peptic ulcer, Prohylaxis of stress ulceration, Prophylaxis of acid aspiration in obstetric patients, Reflux oesophagitis, Risk of acid aspiration in obstetric patients, Short-bowel syndrome, Stress ulcers prevention, Surgical procedures, To reduce degradation of pancreatic enzyme supplements, Zollinger-ellison syndrome, and can also be given in adjunctive therapy as an alternative drug of choice in Benign gastric ulcer, Esophagitis, Gastritis, GI bleeding, Heart burn, Pancreatic insufficiency.
Contraindication of Cimetidine Hcl
Cimetidine (HCl) is contraindicated in conditions like Hypersensitivity.
Side Effects of Cimetidine Hcl
The severe or irreversible adverse effects of Cimetidine (HCl), which give rise to further complications include Tachycardia, Fever, Thrombocytopenia, Aplastic anemia, Aplastic anemia, Stevens johnson syndrome, Impotence, Jaundice, Jaundice, Stevens johnson syndrome, Granulocytopenia, Agranulocytosis, Interstitial nephritis, Acute pancreatitis, Reversible confusion state, Acute pancreatitis, Sinus bradycardia, Gynacomastia, Aplastic anemia, reversible on stoping treatment.,Cimetidine (HCl) produces potentially life-threatening effects which include Cardiac arrhythmia, Heart block. which are responsible for the discontinuation of Cimetidine (HCl) therapy.,The signs and symptoms that are produced after the acute overdosage of Cimetidine (HCl) include no significant adverse effects gave been associated with gross deluberate overdosing.,The symptomatic adverse reactions produced by Cimetidine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Tiredness, Headache, Alopecia, Diarrhea, Fever, Myalgia, Rashes, Confusion, Hallucination, Depression, Arthralgia, Agitation, Confusion, Alopecia, dizziness, plasma creatinine level increase, Sr parathyroid hormone increase, HDL chlosterol level increase.
Precautions of Cimetidine Hcl
Cimetidine should be used with caution in patients with impaired kidney or liver function. Intravenous injection of cimetidine should be given slowly and intravenous infusion is recommended in patients with cardiovascular impairment. Cimetidine can mask the symptoms and allow trasient healing of gastric cancer, the potential delay in diagnosis should particularly be borne in mind in patients of middle age and over with new or recently changed dyspeptic symptoms. In patient on drug treatment or with illness that could cause falls in the blood cell count, the possibility that H2-Receptor antagonism could potentiate this effect should be borne in mind.