Celecoxib (Celecoxib)
Overview of Celecoxib
Celecoxib is an NSAID, a selective inhibitor of cyclo-oxygenase-2 (COX-2). Celecoxib is used in the treatment of rheumatoid arthritis and osteoarthritis. It is also used for ankylosing spondylitis.
Indication of Celecoxib
Celecoxib is primarily indicated in conditions like Ankylosing spondylitis, Osteoarthritis, Rheumatoid arthritis, and can also be given in adjunctive therapy as an alternative drug of choice in Dysmenorrhoea, Pain, Toothache.
Contraindication of Celecoxib
Celecoxib is contraindicated in conditions like Asthma,Urticaria,Hypersensitivity.
Side Effects of Celecoxib
The severe or irreversible adverse effects of Celecoxib, which give rise to further complications include Hepatotoxicity, Gi bleeding, Rhinitis, GI bleeding, Rhinitis, Hepatotoxicity, Myalgia, Urinary tract infection, Bronchitis, Pharyngitis.,Celecoxib produces potentially life-threatening effects which include Myocardial infarction, Hypotension, Heart failure, Death. which are responsible for the discontinuation of Celecoxib therapy.,The signs and symptoms that are produced after the acute overdosage of Celecoxib include Methemoglobinemia.,The symptomatic adverse reactions produced by Celecoxib are more or less tolerable and if they become severe, they can be treated symptomatically, these include Flatulence, Dizziness, Headache, Nausea, Vomiting, Diarrhea, Constipation, Insomnia, Abdominal pain, Rashes, Pruritus, Dyspepsia, Cough, Edema, dizziness, dyspepsia.
Precautions of Celecoxib
It is classifed as pregnancy category C, and should be used with caution during pregnancy only if clearly needed. Avoid use in case of hypersensitivity to celecoxib or any component, sulfonamides, aspirin or other non steroidal anti-inflammatory drugs.