Efavirenz (Efavirenz)
Overview of Efavirenz
Efavirenz is an antiretroviral agent, inhibits non-nucleoside reverse transcriptase enzyme. Efavirenz is used in combination with other antiretroviral drugs in the treatment of HIV infection.
Indication of Efavirenz
Efavirenz is primarily indicated in conditions like Epidural block, surgery, HIV infection.
Contraindication of Efavirenz
Efavirenz is contraindicated in conditions like Breast feeding.
Side Effects of Efavirenz
The severe or irreversible adverse effects of Efavirenz, which give rise to further complications include Insomnia, Amnesia.,The symptomatic adverse reactions produced by Efavirenz are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Nausea, Vomiting, Diarrhea, Anxiety, Abdominal pain, Rashes, Pruritus, Sleep disturbance, Crystalluria, Sinusitis, Abnormal dreams, dizziness, abnormal dreams, Suicidal ideations, Elevated liver enzyme, Fetal Hepatitis.
Precautions of Efavirenz
Chronic hepatitis B or C (greatest risk of hepatic side effects), hepatic impairment (avoid if severe); severe renal impairment; pregnancy; elderly; history of mental illness or seizures. RASH: rash usually in first 2 weeks, is the most common side effect; discontinue if severe rash or if rash accompanied by blistering, oral lesions, conjunctivitis, facial oedema, general malaise, or hypersensitivity reaction; if rash mild to moderate may continue without interruption but usually resolves within 1 month.