Leuprolide acetate (Leuprolide acetate)
Overview of Leuprolide acetate
Leuprolide (Acetate) is a gonadorelin analogue. Leuprolide (Acetate) is used for the supression of gonadal sex hormone secretions, in the treatment of advanced prostate cancera and breast cancer. Leuprolide (Acetate) is used as hormonal therapy in the treatment of endometriosis. Leuprolide is administered parenterally. It was approved by the FDA in April 1985 and came off patent in 1996. The depot formulation of leuprolide is indicated for treating uterine fibroid tumors, endometriosis, and advanced prostate cancer.
Indication of Leuprolide acetate
Leuprolide Acetate is primarily indicated in conditions like Breast cancer, Endometriosis, Intractable premenstrual syndrome, Prostatic cancer, Shrinkage of fibroids before surgery, and can also be given in adjunctive therapy as an alternative drug of choice in Uterine fibroids.
Contraindication of Leuprolide acetate
Leuprolide (Acetate) is contraindicated in conditions like Vaginal bleeding,Hypersensitivity,Lactation.
Side Effects of Leuprolide acetate
The severe or irreversible adverse effects of Leuprolide (Acetate), which give rise to further complications include Leucopenia, Urinary retention, Angina, Bone pain, Myocardial infarction, Flare phenomenon, Urinary retention, Increased size of uterine myomata, Bowel obstruction, Bowel obstruction.,The symptomatic adverse reactions produced by Leuprolide (Acetate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Diarrhea, Palpitation, Light-headedness, Nervousness, Abdominal pain, Peripheral edema, Impotence, Weight gain, Dry skin, Hot flushes, Acne, Gynecomastia, Decrease in libido, Mood changes, nervousness, Nervousness, parasthesia, athralgia, Change in scalp, Body hair.
Precautions of Leuprolide acetate
Leuprolide injection (not the depot) formulation use with caution in the patients hypersensitive to benzyl alcohol. Long-term safety of leuprolide in children has not been established. At the initiation of the therapy tumor flare, bone pain and urinary tract obstruction may occur. Patient with life threatening diseases in which the rapid symptomatic relief is essential should be treated extremely cautiously with leuprolide. The drug should not be administered during pregnancy.