Nafarelin acetate (Nafarelin acetate)
Overview of Nafarelin acetate
Nafarelin (Acetate) is an analogue of gonadorelin with similar properties. Administration of gonadorelin analogues produces stimulation and causes reduction in the release of gonadotrophins (Follicle-stimulating hormone and luteinising hormone), which ultimately leads to inhibition of androgen and estrogen synthesis. Nafarelin (Acetate) is used in the treatment of endometriosis, precocious puberty, infertility anemia due to uterine fibroidsbreast cancer, prostate cancer and prior to intra-uterine surgery.
Indication of Nafarelin acetate
Nafarelin Acetate is primarily indicated in conditions like Benign prostatic hypertrophy, Endometriosis, Preparation of endometrial resection, Shrinkage of fibroids before surgery, and can also be given in adjunctive therapy as an alternative drug of choice in Infertility, Pituitary desensitisation.
Contraindication of Nafarelin acetate
Nafarelin (Acetate) is contraindicated in conditions like Osteoporosis,Vaginal bleeding,Pregnancy,Lactation.
Side Effects of Nafarelin acetate
Nafarelin (Acetate) produces potentially life-threatening effects which include Chest pain, Decreased invertebral trabecular bone mass, Shortness of breath, Urticaria, Pruritis. which are responsible for the discontinuation of Nafarelin (Acetate) therapy.,The symptomatic adverse reactions produced by Nafarelin (Acetate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Myalgia, Rashes, Hot flushes, Acne, Changes in libido, Vaginal dryness, Ovarian cyst, Irritation of nasal mucosa.
Precautions of Nafarelin acetate
Children treated for central precocious puberty should be closely monitored by the physician, during and after nafarelin treatment for central precocious puberty. Possibility of amenorrhea or irregular menstrual periods; checking with physician if regular menstruation does not occur within 60 to 90 days after discontinuation of medication.Using a water-based vaginal lubricant if painful sexual intercourse or vaginal dryness is a problem. Medication should be stopped if pregnany is suspected.