Piretanide (Piretanide)
Overview of Piretanide
Piretanide is a loop diuretic with actions, uses and adverse effects similar to those of frusemide. Piretanide is used in the management of mild to moderate hypertension associated with edema.
Indication of Piretanide
Piretanide is primarily indicated in conditions like Ascites, Chronic liver disease, Hypertension, Nephrotic syndrome, Oedema in congestive heart failure, Pulmonary edema, Renal insufficiency, and can also be given in adjunctive therapy as an alternative drug of choice in Prophylaxis of renal transplant rejection.
Contraindication of Piretanide
Piretanide is contraindicated in conditions like Gout,Hypovolaemia,Hypokalaemia,Anuria,Hepatic coma,Dehydration,Hypersensitivity,Pregnancy,Lactation.
Side Effects of Piretanide
The severe or irreversible adverse effects of Piretanide, which give rise to further complications include Thrombocytopenia, Ototoxicity, Orthostatic hypotension, Dehydration, Leucopenia, Hyponatremia, Urinary retention, Gout.,Piretanide produces potentially life-threatening effects which include Cardiac arrhythmia, Renal failure, Hypotension, Increased renal excretion of Ca, K, Mg. which are responsible for the discontinuation of Piretanide therapy.,The signs and symptoms that are produced after the acute overdosage of Piretanide include Dehydration, Delirium, Hypovolemia, Decreased sodium and water.,The symptomatic adverse reactions produced by Piretanide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Diarrhea, Urticaria, Erythema, Itching, Digestive disturbances.
Precautions of Piretanide
It should be used with caution in patients with diabetes, kidney or liver disease or any drug allergy. Caution must be observed when eating large amounts of food high in potassium such as bananas, baked potatoes, raisins, cooked spinach and other foods. Alcoholic beverages may increase the effects of this drug, causing dizziness or lightheadedness, so limit alcohol intake. It should be used with caution while engaging in activities requiring alertness. This drug changes fluid balance, cause dizziness, if change from a lying to a standing position too rapidly, avoid this by sitting up a few minutes before rising. It should be used with caution during pregnancy or lactation.