Azapropazone (Azapropazone)
Overview of Azapropazone
Azapropazone is a non-steroidal anti-inflammatory drug (NSAID). Azapropazone is a weak inhibitor of cyclooxygenase, but possesses potent uricosuric activity, therefore particularly useful for the treatment of acute gout. Azapropazone is also used for the treatment of rheumatoid arthritis, osteoarthritis.
Indication of Azapropazone
Azapropazone is primarily indicated in conditions like Acute gout attack, Rheumatoid arthritis.
Contraindication of Azapropazone
Azapropazone is contraindicated in conditions like Peptic ulcer,Blood disorders.
Side Effects of Azapropazone
The severe or irreversible adverse effects of Azapropazone, which give rise to further complications include Hepatitis, Pulmonary fibrosis, Erythema multiforme, Agranulocytosis.,Azapropazone produces potentially life-threatening effects which include Autoimmune hemolysis, Non-oliguric renal failure, Coombs +ve hemolytic anemia, Acute intestinal nephritis. which are responsible for the discontinuation of Azapropazone therapy.,The symptomatic adverse reactions produced by Azapropazone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Photosensitivity.
Precautions of Azapropazone
It should not be given in patient with peptic ulceration and should be used with caution in patient with a history of such disorders and with infection, asthma or allergic disorder, impaired renal, hepatic or cardiac function, in elderly and may need to be given in reduce doses. To reduce he risk of gastrointestinal effects, the drug may be taken with or after food or milk.