Saquinavir (Saquinavir)
Overview of Saquinavir
Saquinavir is an agent for treatment of HIV infection. It was the first protease inhibitor to be approved and is the result of a project begun in 1986 to design by computer, molecules that would fit into the active site of the HIV protease enzyme. Synthesis of Saquinavir is a long, 17-step process that has hindered the development of this agent, limiting its commercial availability. Although protease inhibitors are potent antiretroviral agents, resistance to it has been noted following several months of administration.
Indication of Saquinavir
Saquinavir is primarily indicated in conditions like HIV infection.
Contraindication of Saquinavir
Saquinavir is contraindicated in conditions like Hepatic impairment,Hypersensitivity to any component of product.
Side Effects of Saquinavir
The symptomatic adverse reactions produced by Saquinavir are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Diarrhea, Skin RashX, Thrombophlebitis, Hemolytic anemia, Thrombocytopenia, Nephrolithiasis, Abdominal discomfort.
Precautions of Saquinavir
Caution is required in diabetic patient, patients with hemophilia who may experienced increased bleeding. It should be used with caution and possible dose reduction is needed in hepatic impairment. Adequate hydration is recommended to avoid any risk of nephrolithiasis. Monotoring is required in case of renal impairment.