Chlordiazepoxide Hcl (Chlordiazepoxide Hcl)
Overview of Chlordiazepoxide Hcl
Chlordiazepoxide is a 1,4-benzodiazipine. A substituent in the 7th position such as halogen or a nitro group is required for its sedative, and hypnotic activity. Benzdiazipines are the most widely used anxiolytic drugs. The benzodiazipines are more effective and safer. They have largely replaced barbiturates and meprobamates in the treatment of anxiety.
Indication of Chlordiazepoxide Hcl
Chlordiazepoxide Hcl is primarily indicated in conditions like Acute alcohol withdrawal, Adjunct in acute alcohol withdrawal, Adjunt in acute alcohol withdrawal, Anxiety, Insomnia, Muscular spasm, Premedication in anaesthesia, Psychosomatic disorders, Suppression of transplant rejection, and can also be given in adjunctive therapy as an alternative drug of choice in Alcohol withdrawal.
Contraindication of Chlordiazepoxide Hcl
Chlordiazepoxide (HCl) is contraindicated in conditions like Depression,Pulmonary insufficiency,Respiratory depression.
Side Effects of Chlordiazepoxide Hcl
The severe or irreversible adverse effects of Chlordiazepoxide (HCl), which give rise to further complications include Psychological impairment, Cerebral atrophy, Psychomotor performance impairment.,Chlordiazepoxide (HCl) produces potentially life-threatening effects which include Hemolytic anemia, Hypoplastic Anemia. which are responsible for the discontinuation of Chlordiazepoxide (HCl) therapy.,The signs and symptoms that are produced after the acute overdosage of Chlordiazepoxide (HCl) include Coma, Drowsiness, Confusion, Ataxia, Sedation.,The symptomatic adverse reactions produced by Chlordiazepoxide (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Skin reactions, Aggression, Dependence.
Precautions of Chlordiazepoxide Hcl
Perform periodic blood counts and liver function tests during long term therapy of chlordiazepoxide. It should be used with caution in patients if increased salivation cause respiratory difficulty, because it may produce an increase in salivation. Give least amount of drug to patients in whom depression accompanies anxiety and suicidal tendencies may be present. It should be used with caution (if it contains tartrazine) in patients with aspirin hypersensitivity because it may cause allergic reaction (including bronchial asthma).