Dolasetron (Mesylate) (Dolasetron (Mesylate))
Overview of Dolasetron (Mesylate)
Dolasetron (Mesylate) is a specific 5HT-3 antagonist, similar to ondensetron. It block 5HT-3 receptors in the gastrointestinal tract and in the CNS. Dolasetron (Mesylate) is used chiefly in the management of nausea and vomiting induced by cytotoxic drugs during chemotherapy or in post-operative nausea and vomiting.
Indication of Dolasetron (Mesylate)
Dolasetron Mesylate is primarily indicated in conditions like Nausea and vomiting (chemotherapy induced), Nausea and vomiting (prevention), Nausea and vomiting (radiothrapy induced).
Contraindication of Dolasetron (Mesylate)
Dolasetron (Mesylate) is contraindicated in conditions like Heart disease,Hypersensitivity.
Side Effects of Dolasetron (Mesylate)
The signs and symptoms that are produced after the acute overdosage of Dolasetron (Mesylate) include Hypotension, Dizziness, Metastatic Melenoma.,The symptomatic adverse reactions produced by Dolasetron (Mesylate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Headache, Drowsiness, Fatigue, Diarrhea, Constipation, Abdominal pain, Hot flushes, Abnormal LFT, Hypertension, Symptomatic cardiovascular events, QT prolongation, dizziness, Abnormal LFT.
Precautions of Dolasetron (Mesylate)
It should be used with caution in patients with severe renal failure or severe hepatic failure.