Crisantaspase (Crisantaspase)
Overview of Crisantaspase
Crisantaspase is an enzyme asparaginase produced by Erwinia chrysanthemi, which acts as an anti-neoplastic agent. It breaks down the aminonacid L-asparaginase to aspartic acid and ammonia, and interferes with the growth of malignant cells, which unlike most healthy cells, are unable to synthesise L-asparaginase for their metabolism. Crisantaspase is used almost exclusively in acute lymphoblastic leukaemia.
Indication of Crisantaspase
Crisantaspase is primarily indicated in conditions like Acute leukemia, Acute lymphocytic leukemia, Hypersensitivity of E.Coli, Lymphoblastic lymphoma, Lymphoid malgnancies, Non-hodgkin's lymphoma, Non-hodgkin's lymphoma.
Contraindication of Crisantaspase
Crisantaspase is contraindicated in conditions like Hypersensitivity,Pregnancy.
Side Effects of Crisantaspase
The severe or irreversible adverse effects of Crisantaspase, which give rise to further complications include Hepatotoxicity, Coma, Hemorrhage, Hepatotoxicity, Thrombosis, Stupor, Tremors, Hypermylasia, Hemorrhagic pancreatitis.,Crisantaspase produces potentially life-threatening effects which include Hypotension, Bronchospasm, Bronchospasm, Anaphylaxis, Laryngeal edema, Urticaria. which are responsible for the discontinuation of Crisantaspase therapy.,The symptomatic adverse reactions produced by Crisantaspase are more or less tolerable and if they become severe, they can be treated symptomatically, these include Abdominal distension, Drowsiness, Fatigue, Nausea, Vomiting, Fever, Abdominal pain, Confusion, Hyperglycemia, Increased serum bilirubin, Increased cholestrol, Hepatomegaly, Malabsorption, Confusion.
Precautions of Crisantaspase
Therapy should only be given where there are adequate facilities for ventilation and monitoring.