Alglucerase (Alglucerase)
Overview of Alglucerase
Alglucerase is a modified form of human placental enzyme (ß-glucocerebrosidase), and a monomeric glycoprotien containing 497 amino acids with glycosylation. Alglucerase is used as enzyme replacement therapy.
Indication of Alglucerase
Alglucerase is primarily indicated in conditions like Gauchers disease (type I).
Contraindication of Alglucerase
Alglucerase is contraindicated in conditions like Prostatic cancer,Skeletal disease,Allergy to serum albumin.
Side Effects of Alglucerase
The severe or irreversible adverse effects of Alglucerase, which give rise to further complications include Upper airway inflammation, Sense of laryngeal constriction.,The symptomatic adverse reactions produced by Alglucerase are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Vomiting, Fever, Abdominal cramps, Chills, Urticaria, Pruritus, Allergic reactions, Flushing, Cough, Virilization, Angioedema, Chest tightness, Discomfort, Reaction at injection site.
Precautions of Alglucerase
Caution is required in patient who have exhibited sign of hypersenitivity, if hypersensitivity reaction occurs the drug should be discontinued. It is prepared from human placenta therefore carries a risk of transmission of infection. It should be used with caution in patient with androgen-sensitive malignancies. It is classified as pregnancy cateogry C. It should be used with caution during pregnancy and only when the benefit outweighs the risk.