Cefoxitin (Cefoxitin)
Overview of Cefoxitin
Cefoxitin is a second generation, semisynthetic cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cefoxitin is effective against a wide variety of gram positive and gram negative organisms, with strong resistance to ß lactamase. Cefoxitin is less effective against gram positive bacteria than first generation drugs. Antibiotics require constant drug level in body for therapeutic effect.This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cefoxitin is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.
Indication of Cefoxitin
Cefoxitin is primarily indicated in conditions like Bone and joint infection, Endometritis, Female genital tract infection, Gonorrhoea, Intra-abdominal infections, Pelvic infections, Peritonitis, Persistant neutropenia in advanced hiv infection, Renal impairment, Respiratory tract infections, Septicaemia, Surgical infections, Surgical prophylaxis, Urinary tract infection.
Contraindication of Cefoxitin
Cefoxitin is contraindicated in conditions like Colitis.
Side Effects of Cefoxitin
The severe or irreversible adverse effects of Cefoxitin, which give rise to further complications include Thrombocytopenia, Hemolytic anemia, Hemolytic anemia, Hypersensitivity reactions, Eosinophilia, Eosinophilia, Renal failure, Transient leucopenia, Neutropenia, Hemolytic anemia.,Cefoxitin produces potentially life-threatening effects which include Pseudomembranous colitis, Anaphylactic reactions. which are responsible for the discontinuation of Cefoxitin therapy.,The symptomatic adverse reactions produced by Cefoxitin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Diarrhea, Pseudomembranous colitis, Thrombophlebitis.
Precautions of Cefoxitin
Cefoxitin should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs.It should be given with caution in allergic reactions.