Glycine (Glycine)
Overview of Glycine
Glycine is the smallest of the amino acids, non-essential amino acid occuring as a constituents of many proteins. Chemically itaminoacetic acid. It is a glycogenic and participates in variety of synthetic reactions. Glycine is used with antacid in stomach hyperacidity, also with aspirin to reduce its stomach irritation.
Indication of Glycine
Glycine is primarily indicated in conditions like Bladder irrigation, Urogenital tract inflammation, and can also be given in adjunctive therapy as an alternative drug of choice in Hyperacidity.
Contraindication of Glycine
Glycine is contraindicated in conditions like Anuria.
Side Effects of Glycine
The severe or irreversible adverse effects of Glycine, which give rise to further complications include Pulmonary toxicity, Cardiovascular toxicity, Hyperammonemia.,The symptomatic adverse reactions produced by Glycine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Electrolyte imbalance.
Precautions of Glycine
Glycine should be used with caution in patients with liver impairment. Avoid use in patients with anuria.Hepatic impairment as any absorption and consequent metabolism may cause hyperammonaemia. Cardiopulmonary dysfuntion . CV status before and during treatment in pateints with cardiac disease.