Carboplatin (Carboplatin)
Overview of Carboplatin
Carboplatin is an alkylating anticancerous drug. Carboplatin is a platinium co-ordination compound having the same mechanism of action as cisplatin. Carboplatin is effective in the treatment of ovarian cancer, non-small cell lung cancer, germ cell , head and neck, and oesophageal cancers. Carboplatin is used alone or in combination with different anti-cancerous drugs to obtain best therapeutic effects and to reduce side effects or toxicities.
Indication of Carboplatin
Carboplatin is primarily indicated in conditions like Advanced ovarian cancer, Head and neck cancer, Lung cancer, Ovarian cancer, Small cell lung cancer, and can also be given in adjunctive therapy as an alternative drug of choice in Colorectal cancer, Gastric cancer, Malignant lymphoma, Non-small cell lung carcinoma.
Contraindication of Carboplatin
Carboplatin is contraindicated in conditions like Allergy.
Side Effects of Carboplatin
The severe or irreversible adverse effects of Carboplatin, which give rise to further complications include Nephrotoxicity, Hepatotoxicity, Gi bleeding, Ototoxicity, Blood dyscrasias, Peripheral neuropathy.,Carboplatin produces potentially life-threatening effects which include Thrombocytopenia, Myelosuppression. which are responsible for the discontinuation of Carboplatin therapy.,The symptomatic adverse reactions produced by Carboplatin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vomiting, Alopecia, Anorexia, Diarrhea, Myalgia, Blurred vision, Rashes, Malaise, Asthenia, Arthralgia, Pain at injection site.
Precautions of Carboplatin
Carboplatin should be used with caution in patients with pre-existing blood disorders or bone marrow disease, kidney disease or any allergy. Carboplatin is classified as pregnancy category D and should be avoided during pregnancy or lactation.