Oxethazaine (Oxethazaine)
Overview of Oxethazaine
Oxethazaine is amide anesthetic, witha prolong duration of action. Oxethazaine is designated as N, N-bis-(N-methyl-N-phenyl-butyl-acetamide)-betahydroxyethylamine. Oxethazaine is given by mouth along with antacid for the symptomatic relief of gastro-oesophageal reflux disease. Oxethazaine is also used in the ointments and suppositories for the relief of pain associated with haemorrhoids.
Indication of Oxethazaine
Oxethazaine is primarily indicated in conditions like Esophagitis, Oesopghagitis, Reflux oesophagitis, and can also be given in adjunctive therapy as an alternative drug of choice in Haemorrhoids, Hemorrhoids.
Contraindication of Oxethazaine
Oxethazaine is contraindicated in conditions like Hypersensitivity to any component of product.
Side Effects of Oxethazaine
The signs and symptoms that are produced after the acute overdosage of Oxethazaine include Drowsiness, Dizziness, Fainting.,The symptomatic adverse reactions produced by Oxethazaine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Pruritus, Hypersensitivity reactions, Glossitis, Idosyncratic rashes.
Precautions of Oxethazaine
The use of magnesium-containing antacids in patients with mild to moderate renal impairment should be carefully monitored due to a possible increased danger of hypermagnesemia. Hypophosphatemia may occur with prolonged administration or large doses of aluminum-containing antacids (except aluminum phosphate) especially in patients with an inadequate dietary intake of phosphorus.