Levosulpiride (Levosulpiride)
Overview of Levosulpiride
Levosulpiride is a substituted benzamide antipsychotic which is reported to be a selective antagonist of central dopamine (D-2, D-3 and D-4) receptors. Levosulpiride is also calimed to have mood elevating properties. Levosulpiride is used in the treatment of psychoses such as schizophrenia, anxiety disorders, vertigo and also in peptic ulceration.
Indication of Levosulpiride
Levosulpiride is primarily indicated in conditions like Anxiety, Depression, Gastro-esophageal reflux disease, Irritable bowel syndrome, Schizophrenia, Tourette's syndrome, and can also be given in adjunctive therapy as an alternative drug of choice in Peptic ulcer, Vertigo.
Contraindication of Levosulpiride
Levosulpiride is contraindicated in conditions like Epilepsy,Hyperprolactinaemia,Mania,Gastrointestinal hemorrhage,pheochromocytoma,Breast feeding,Hypersensitivity to any component of product.
Side Effects of Levosulpiride
The severe or irreversible adverse effects of Levosulpiride, which give rise to further complications include Amenorrhea, Gynacomastia, Galactorrhea, Changes in libido.,Levosulpiride produces potentially life-threatening effects which include Neuroleptic Malignant Syndrome, Neuroleptic malignant syndrome. which are responsible for the discontinuation of Levosulpiride therapy.,The symptomatic adverse reactions produced by Levosulpiride are more or less tolerable and if they become severe, they can be treated symptomatically, these include Sedation, Sleep disturbance, Hypotension, Gynecomastia, Galactorrhea, Agitation, Dyskinesia, Overstimulation, Hyperprolactinemia, Tardive dyskinesia.
Precautions of Levosulpiride
Should be use with caution in porphyria,renal impairment and mania and in patients receiving antihypertensive, hypnotic and analgesic drugs, because concurrent use may increase the effects of these drugs.should be given with care to hypomanic pateints.